North Gulfport Cannabis Guide: Gulfport, Mississippi

Gulfport grew inland along Highway 49 long before cannabis was legal here, and the retail map simply followed that spine. Four licensed counters operate on the highway itself at 9113, 9354, 11370 and 12407, all inside the 39503 zip north of Interstate 10, with a fifth nearby on Creosote Road at 15223. The remaining two sit far from that cluster: 2159 East Pass Road on the Biloxi side of town and 2709 25th Avenue in the old downtown grid near the harbor.

That north-heavy distribution tells you where the city actually lives now. Orange Grove, Gulfport Lakes and the subdivisions off Lyman have absorbed decades of growth while the historic waterfront turned toward the Mississippi Aquarium, Jones Park and cruise-adjacent tourism. Harrison County as a whole registered 7,631 medical patients, the highest county total in the state, and carries 21 dispensary business licenses. Only 18 certifying practitioners serve all of it, so appointment waits are the real bottleneck rather than store access.

Two practical notes for anyone shopping here. Gulfport charges no municipal cannabis levy, so the register shows the plain 7 percent state sales tax, unlike Jackson and Tupelo. And the Port of Gulfport, the Air National Guard's Combat Readiness Training Center and the Seabee base a few miles east in Gulfport are all federal or federally controlled ground where a Mississippi registry card has no standing whatsoever.

Two agencies split the job here, and knowing which one to call saves you a wasted afternoon. The Mississippi State Department of Health runs the Mississippi Medical Cannabis Program: it registers patients and caregivers, approves certifying practitioners, and licenses growers, processors, labs, transporters and disposal firms. The Department of Revenue, through its Alcoholic Beverage Control enforcement division, licenses and polices the dispensaries themselves. Patient questions go to MCRegistration@msdh.ms.gov; complaints about a store go to the ABC permit desk.

The market is no longer new. Health department figures put active patients at 66,041 at the close of 2025, up from 49,626 a year earlier, and the transparency portal showed 70,300 approved patient registrations by September 2026. Retail sales reached $138,863,945 across calendar 2025. Cultivators pay a 5 percent excise tax on their first transfer of flower or trim; you pay the ordinary 7 percent state sales tax at the counter, plus a local levy if you shop in Jackson or Tupelo. Statewide averages published by the program put flower at $22.50 per unit and concentrate near $44.

Senate Bill 2748, effective July 1, 2025, made the most consequential change since launch. It redefined one Mississippi Medical Cannabis Equivalency Unit for infused products as a full gram of total THC instead of 100 milligrams, which multiplied how many gummies a 24-unit monthly allotment actually buys. The same bill opened telemedicine certification for homebound and bedbound patients and barred license applicants from filing for local zoning before the state signs off.

The 2026 session changed nothing. Bills to lift the potency ceilings, drop the six-month follow-up visit, let caregivers buy without the patient present, regulate hemp THC retail and ban hemp drinks all died before a floor vote.

Mississippi grows and processes everything it sells, so the brand shelf is entirely home-grown and rotates fast. Health department counts for 2025 listed 53 cultivation and 57 micro-cultivation licensees feeding 17 processors and 20 micro-processors, with only two testing labs certifying the whole supply. That concentration is worth knowing: when a lab bulletin goes out, it moves inventory across the entire state at once. Rather than chase a house name, ask the agent which cultivator grew the batch, then read the certificate of analysis for total THC, terpene percentage and the harvest date. The program publishes a plain-English guide to reading a COA on its patient resources page.

Dispensary count peaked and then thinned. The health department logged 200 stores at the end of 2024 and 171 by December 29, 2025, while sales still climbed to $138.9 million, which means the survivors absorbed the closures. The registry was back to 191 records by September 2026. Cultivation licenses fell from 61 to 53 over the same stretch and testing labs dropped from four to two. Consolidation, not contraction, is the honest read.