Hoffmeyer Road Cannabis Guide: Florence, South Carolina

Florence exists where I-95 and I-20 cross, and that junction defines the city more than anything else. It is the Pee Dee's medical hub through McLeod Health and MUSC Health Florence, a freight and distribution center, and the place where an enormous volume of East Coast traffic passes through daily. Francis Marion University sits just east of town. None of that produces a legal cannabis market, because South Carolina has never authorized one.

The interstate reality is the local reality. Drivers moving between Florida, Georgia and the Northeast pass through here constantly, and a substantial share of Florence County drug cases begin as a traffic stop on I-95. Product bought legally in Maryland, New Jersey or Massachusetts is illegal contraband the moment it enters South Carolina, and neither a dispensary bag nor an out-of-state medical card changes the charge. More than an ounce triggers the statutory presumption of distribution, and that is where felony charges begin.

Legal retail sits on the city's commercial spines. Palmetto Street carries the largest run of tobacco outlets and vape shops stocking hemp gummies, disposables and drinks, with more along South Irby Street, Second Loop Road toward the Magnolia Mall area, and at the interstate exits themselves. Grocery coolers in west Florence stock seltzer four-packs. Every retailer along them is carrying stock that will not be legal to sell once the federal container cap arrives in December 2026, and for a Palmetto Street or Second Loop store, local search is the only place a customer can find them.

South Carolina sits in a small group of states with no medical cannabis law of any kind. There is no patient registry, no qualifying-conditions list, no license category for a dispensary, and no agency assigned to regulate marijuana, because the plant is still a Schedule I controlled substance under Title 44, Chapter 53 of the state code. Carrying an ounce or less is a misdemeanor: up to 30 days in jail or a fine of $100 to $200 on a first conviction, and up to a year on a second. Anything over an ounce triggers a statutory presumption of intent to distribute, which is where the felony exposure starts.

The Compassionate Care Act, S.53, filed by Sen. Tom Davis of Beaufort in December 2024, would have created a pharmacist-dispensed medical program with no smokable flower and no home cultivation. It went to Senate Medical Affairs in January 2025 and never got a committee vote. An earlier version passed the Senate 28-15 in February 2022 before the House ruled it out of order. Gov. Henry McMaster has publicly called the case for medical cannabis compelling. It is still not law.

What South Carolinians actually buy is hemp. The 2019 Hemp Farming Act put cultivation and processing under the Department of Agriculture and adopted the federal 0.3 percent delta-9 threshold, and the consumable side grew into a roughly $60 million retail category with no state rules attached to it. Lawmakers spent all of 2026 trying to fix that. A Senate compromise in March would have capped gummies and drinks at 10mg per serving and restricted sales to adults 21 and older; a House version, H.4759, proposed 5mg per 12-ounce can under an alcohol-style permit. The conference report on H.3924 died on a 28-69 House vote on June 25, 2026. Nothing passed, so nothing changed.

Two enforcement realities sit on top of that. Attorney General Alan Wilson has held since an October 2021 advisory opinion that delta-8 and other converted isomers are not protected by the Hemp Farming Act, and SLED operates on that reading; Operation Ganjapreneur seized about 15 tons of product in December 2025. And federally, Section 781 of the 2026 appropriations law redefines hemp by total THC and caps finished consumable products at 0.4mg per container. A stopgap signed September 2, 2026 pushed most of that to December 11, 2026.

No marijuana brand operates legally in South Carolina, so the honest list is hemp only. Palmetto Harmony, based in Conway, grows, extracts and bottles in state and was the first vertically integrated hemp CBD company to get USDA organic certification on flower and viable seed - the closest thing South Carolina has to a homegrown label. In beverages, Crescent Canna's Crescent 9 seltzer is stocked at The Fresh Market locations across the state, and Wynk ships its low-dose delta-9 cans direct to South Carolina addresses. Beyond those two, judge a can by its label rather than its reputation. Beyond those, judge by paperwork rather than logo: a current certificate of analysis from an independent lab, batch number matching the package, and total THC listed rather than delta-9 only.

Two clocks are running. The first is legislative: S.53 never cleared its Senate committee this session, and 2027 restarts the process from scratch, with Sen. Davis expected to refile. The second is federal: Section 781 of H.R. 5371 redefines hemp by total THC and caps finished consumables at 0.4mg per container, and after the September 2, 2026 stopgap most of it lands December 11, 2026, with lab-made cannabinoids losing hemp status a month earlier. South Carolina never passed its own hemp rules, so it will absorb the federal version by default. Retailers should expect shelf-clearing, not a grace period.